Professor of Chemistry

Phone: (86)27-87793907

Email: zs_shi@hust.edu.cn

Academic Areas: Protein/Peptide and PNA

Shi Zhengshuang is currently a professor at School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology. The problems in which he is currently most interested include protein folding and energetics, antimicrobial peptides and functional design based on peptides and PNAs.

Academic Degrees

PhD in Biophysical Chemistry, 2002, Department of Chemistry, New York University;

MS in Organic Chemistry, 1995, Shanghai Institute of Organic Chemistry, CAS;

BS in Chemistry, 1992, Department of Chemistry, Lanzhou University 

Professional Experience

Huazhong University of Science and Technology School of Chemistry and Chemical Engineering, Professor (2010- ); New York University Department of Chemistry, Sr. Research Scientist (2009-2010); University of Colorado at Boulder Department of Chemistry and Biochemistry, HHMI postdoctoral associate (2006-2009); University of Pennsylvania School of Medicine, postdoctoral fellow (2002-2005) 

Selected Publications

1. HE L, NAVARRO AE, SHI ZS* and KALLENBACH NR*; End Effects Influence Short Model Peptide Conformation;Journal of the American Chemical Society 134, 1571–1576, 2012.
2. YOUNG AW, LIU ZG, ZHOU CH, TOTSINGAN F, JIWRAJKA N, SHI ZS* and KALLENBACH NR*; Structure and Antimicrobial Properties of Multivalent Short Peptides; MedChemComm 2, 308–314, 2011.
3. SHI ZS and KALLENBACH NR; Ramachandran Redux; Proceedings of the National Academy of Sciences USA 108, 3-4, 2011.
4. HOU SY, ZHOU CH, LIU ZG, YOUNG AW, SHI ZS, REN DC and KALLENBACH NR; Antimicrobial dentrimer active against E coli biofilms; Bioorganic & Medicinal Chemistry Letters 19, 5478-5481, 2009.
5. SHI ZS, RESING KA and AHN NG; Networks for the allosteric control of protein kinases; Current Opinion in Structural Biology 16, 686-692, 2006.
6. SHI ZS, CHEN K, LIU ZG and KALLENBACH NR; Conformations of the backbone in unfolded proteins; Chemical Reviews 106, 1877-1897, 2006.
7. SHI ZS, PETERSON RW and WAND AJ; New Reverse Micelle Surfactant Systems Optimized for High-Resolution NMR Spectroscopy of Encapsulated Proteins; Langmuir, 21, 10632–10637, 2005.
8. SHI ZS, CHEN K, LIU ZG, NG A, BRACKEN WC and KALLENBACH NR; Polyproline II propensities from GGXGG reveal an anti-correlation with the beta-sheet scale; Proceedings of the National Academy of Sciences USA 102, 17964-17968, 2005.
9. CHEN K, LIU ZG, ZHOU CH, SHI ZS and KALLENBACH NR; Neighbor Effect on PPII Conformation in Alanine Peptides; Journal of the American Chemical Society 127,10146–10147, 2005.
10. LIU ZG, CHEN K, NG A, SHI ZS, WOODY RW and KALLENBACH NR; Solvent Dependence of PII Conformation in Model Alanine Peptides; Journal of the American Chemical Society 126, 15141–15150, 2004.
11. DING L, CHEN K, SANTINI PA, SHI ZS and KALLENBACH NR; The Pentapeptide GGAGG Has PII Conformation; Journal of the American Chemical Society 125, 8092–8093, 2003.
12. SHI ZS, OLSON CA, ROSE GD, BALDWIN RL and KALLENBACH NR; Polyproline II structure in a sequence of seven alanine residues;Proceedings of the National Academy of Sciences USA 99, 9190-9195, 2002.
13. SHI ZS, OLSON CA and KALLENBACH NR;Cation-pi interaction in model α-helical peptides;Journal of the American Chemical Society 124, 3284-3291, 2002.
14. SHI ZS, OLSON CA, KALLENBACH NR and SOSNICK TR; D/H amide isotope effect in model α-helical peptides; Journal of the American Chemical Society 124, 13994-13995, 2002.
15. SHI ZS, KRANTZ BA, KALLENBACH NR and SOSNICK TR;Contribution of Hydrogen Bonding to Protein Stability Estimated from Isotope Effects;Biochemistry 41, 2120–2129, 2002.
16. SHI ZS, WOODY RW and KALLENBACH NR;Is polyproline II the major backbone conformation in unfolded proteins? Advances in Protein Chemistry 62, 163-240, 2002.
17. OLSON CA, SHI ZS and KALLENBACH NR; Polar Interactions with Aromatic Side Chains in α-Helical Peptides: CH•••O H-Bonding and Cation-π Interactions; Journal of the American Chemical Society 123, 6451–6452, 2001.
18. SPEK EJ, OLSON CA, SHI ZS and KALLENBACH NR; Alanine is an intrinsic α-helix stabilizing amino acid; Journal of the American Chemical Society 121, 5571-5572, 1999.

 

Awards and Honors

Margaret and Herman Sokol Award for postdoctoral research (2003)

Courses Taught

General Chemistry & General Chemistry Lab (International Undergraduate Student);

Chemical Biology (PhD graduate student) 

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