Associate Professor of Inorganic Chemistry

Email: lihailing86@hust.edu.cn

Academic Areas: Biological Inorganic Chemistry

Hailing Li is the associate professor of Biological Inorganic Chemistry. Her research interest focuses on iron overload diseases. These researches including the study on the effects of iron overload on animal tissues and inhibitory effects of nature products. As a first author or corresponding author, she has published more than 10 papers in peer reviewed international journals such as Biochimie, Eur J Pharmacol, Food Chem Toxicol, etc. Li teaches some courses such as Inorganic Chemistry, Inorganic Chemistry Experiments and General Chemistry for undergraduate students.

Academic Degrees

2008

PhD in Inorganic Chemistry, Huazhong University of Science & Technology

1999

MS in Applied Chemistry, Huazhong University of Science & Technology

Professional Experience

2000-2011

Instructor, School of Chemistry & Chemical Engineering, HUST

2011-now

Associate Professor, School of Chemistry & Chemical Engineering, HUST

Courses Taught

1.Basic Chemistry (for undergraduate student)

2.Inorganic Chemistry Experiments (for undergraduate student)

Awards and Honors

Selected Projects Funded

1.National Science Foundation of China (No. 32071282)

Selected Publications

[1]Jinming Wu, Xiaoying Yin, Huixian Ye, Zhonghong Gao*, Hailing Li*.  Structure relationship of metalloporphyrins in inhibiting the aggregation of hIAPP. International Journal of Biological Macromolecules. 2021, 167:141-150

[2]Huixian Ye, Hailing Li*, Zhonghong Gao*. Y12 nitration of human calcitonin (hCT): A promising strategy to produce non-aggregation bioactive hCT. Nitric Oxide. 2020, 104-105: 11-19

[3]Pengfei Zhang, Lizhen Zeng, Wanxia Gao, Hailing Li*, Zhonghong Gao*. Peroxynitrite scavenger FeTPPS effectively inhibits hIAPP aggregation and protects against amyloid induced cytotoxicity. International Journal of Biological Macromolecules. 2020, 161：336-344

[4]Xu Fang, Wanxia Gao, Zhen Yang, Zhonghong Gao*, Hailing Li*. Dual anti/pro-oxidant behaviors of flavonoids pertained to Cu (II) catalyzed tyrosine nitration of insulin receptor kinase domain in the anti-diabetic study. Journal of Agricultural and Food Chemistry. 2020, 68(22): 6202-6211

[5]Jiayu Li, Zhen Yang, Hailing Li*, Zhonghong Gao*. Structure effect of water-soluble iron porphyrins on catalyzing protein tyrosine nitration in the presence of nitrite and hydrogen peroxide. Nitric Oxide. 2019, 91:42-51    

[6]Huixian Ye, Jun Zhou, Hailing Li*, Zhonghong Gao*. Heme prevents highly amyloidogenic human calcitonin (hCT) aggregation: a potential new strategy for the clinical reuse of hCT. Journal of Inorganic Biochemistry. 2019, 196: 110686   

[7]Jie Zhao, Jinming Wu, Zhen Yang, Lei Ouyang, Lihua Zhu, Zhonghong Gao*, Hailing Li*. Nitration of hIAPP promotes its toxic oligomer formation and exacerbates its toxicity towards INS-1 cells. Nitric Oxide. 2019, 87：23-30   

[8]Jie Zhao, Wanxia Gao, Zhen Yang, Hailing Li*, Zhonghong Gao*. Nitration of amyloid-β peptide (1-42) as a protective mechanism for the amyloid-β peptide (1-42) against copper ion toxicity. Journal of Inorganic Biochemistry. 2019, 190:15-23

[9]Peipei Wang, Jinming Wu, Zhonghong Gao, Hailing Li*. Tyrosine residues of bovine serum albumin play an important role in protecting SH-SY5Y cells against heme/H2O2/NO2--induced damage. Molecular and Cellular Biochemistry. 2019, 454(1-2): 57-66     

[10]Pengfei Zhang, Lu Ma, Zhen Yang, Hailing Li*, Zhonghong Gao*. Study on the detoxification mechanisms to 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron(III) chloride (FeTPPS), an efficient pro-oxidant of heme water-soluble analogue. Journal of Inorganic Biochemistry. 2018, 189: 40-52 

[11]Huixian Ye, Hailing Li*, Zhonghong Gao*. Copper binding induces nitration of NPY under nitrative stress: complicating the role of NPY in Alzheimer's Disease. Chemical Research in Toxicology. 2018, 31(9):904-913

[12]Pengfei Zhang, Lu Ma, Zhen Yang, Hailing Li*, Zhonghong Gao*. 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinato iron(III) chloride (FeTPPS), a peroxynitrite decomposition catalyst, catalyzes protein tyrosine nitration in the presence of hydrogen peroxide and nitrite. Journal of Inorganic Biochemistry. 2018, 183: 9-17

[13]Jinming Wu, Jie Zhao, Zhen Yang, Hailing Li*, Zhonghong Gao*. A strong inhibitory effect of heme on hIAPP fibrillation. Chemical Research in Toxicology. 2017, 30(9):1711-1719 

[14]Yi Huang, Zhen Yang, Huan Xu, Pengfei Zhang, Zhonghong Gao, Hailing Li*. Insulin enhances the peroxidative activity of heme by forming heme-insulin complex: relevance to type 2 diabetes mellitus. International Journal of Biological Macromolecules. 2017, 102: 1009-1015