Professor of Chemistry

Phone: +86 15872425950

Email: xswu@hust.edu.cn

Academic Areas: Organic Chemistry

Research in the Wu research group is primarily aimed toward the development of new strategies and methodologies for organic synthesis. We are interested in using these methods to address problems in the synthesis of important molecules for use in materials science, pharmaceuticals, and molecular biology.

Academic Degrees

2006-2012

Ph. D. in Organic Chemistry, University of Science and Technology of China

2002-2006

B. S. in Chemistry, University of Science and Technology of China

Professional Experience

2017-now

Professor, Huazhong University of Science and Technology

2015-2017

Postdoctoral Scholar, University of California Irvine

2012-2015

Postdoctoral Fellow, Indiana University-Purdue University Indianapolis

Courses Taught

Awards and Honors    

Selected Projects Funded

Selected Publications

1. Wu, X.#; Cruz, F.#; Lu, A.; Dong, V. M. “Tandem Catalysis: Transforming Alcohols to Alkenes by an Oxidative Dehydroxymethylation” J. Am. Chem. Soc. 2018, 140, 10126-11593.

2. Wu, X.; Riedel, J.; Dong, V. M. “Transforming Olefins into γ,δ-Unsaturated Nitriles through Copper Catalysis” Angew. Chem. Int. Ed. 2017, 56, 11589-11593.

3. Wu, X.; Chen, Z.; Bai, Y.; Dong, V. M. “Diastereodivergent Construction of Bicyclic γ-Lactones via Enantioselective Ketone Hydroacylation” J. Am. Chem. Soc. 2016, 138, 12013-12016.

4. Wu, X.; Miao, J.; Li, Y.; Li, G.; Ge, H. “Copper-Promoted Site-Selective Carbonylation of sp3 and sp2 C–H Bonds with Nitromethane” Chem. Sci. 2016, 7, 5260-5264.

5. Wu, X.; Zhao, Y.; Ge, H. “Pyridine-Enabled Copper-Promoted Cross Dehydrogenative Coupling of C(sp2)−H and Unactivated C(sp3)−H Bonds” Chem. Sci. 2015, 6, 5978-5983.

6. Wu, X.; Wang, M.; Zhang, G.; Zhao, Y.; Wang, J.; Ge, H. “Copper-Catalyzed Diastereoselective Aerobic Intramolecular Dehydrogenative Coupling of Hydrazones via sp3 C−H Functionalization” Chem. Sci. 2015, 6, 5882-5890.

7. Wu, X.; Zhao, Y.; Ge, H. “Direct Aerobic Carbonylation of C(sp2)−H and C(sp3)−H Bonds through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source” J. Am. Chem. Soc. 2015, 137, 4924-4927.

8 Wu, X.; Yang, K.; Zhao, Y.; Sun, H.; Li, G.; Ge, H. “Cobalt-Catalysed Site-Selective Intra- and Intermolecular Dehydrogenative Amination of Unactivated sp3 Carbons” Nature Communications 2015, 6: 6442.

9. Wu, X.; Zhao, Y.; Ge, H. “Copper-Promoted Site-Selective Acyloxylation of Unactivated C(sp3)–H Bonds” Chem. Asian J. 2014, 9, 2736-2739.

10. Wu, X.; Zhao, Y.; Ge, H. “Nickel-Catalyzed Site-Selective Amidation of Unactivated C(sp3)–H Bonds” Chem. Eur. J. 2014, 20, 9530-9533.

11. Wu, X.; Zhang, G.; Zhao, Y.; Ge, H. “Copper-Catalyzed Site-Selective Intramolecular Amidation of Unactivated C(sp3)–H Bonds” Angew. Chem. Int. Ed. 2014, 53, 3706-3710.

12. Wu, X.; Zhao, Y.; Ge, H. “Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp3)–H Bonds” J. Am. Chem. Soc. 2014, 136, 1789-1792.

13. Wu, X.; Zhou, M.-G.; Chen, Y.; Tian, S.-K. “Catalytic Allylation of Hypophosphorous Acid and H-Phosphinic Acids with Primary Allylic Amines” Asian J. Org. Chem. 2014, 3, 711-714.

14. Wu, X.; Chen, Y.; Li, M.-B.; Zhou, M.-G.; Tian, S.-K. “Direct Substitution of Primary Allylic Amines with Sulfinate Salts” J. Am. Chem. Soc. 2012, 134, 14694-14697.

15. Wu, X.; Tian, S.-K. “Catalytic Asymmetric Cleavage of sp3 C–N Bonds for Access to Highly Enantioenriched N-Benzylic Sulfonamides” Chem. Commun. 2012, 48, 898-900.

16. Shao, Y.-D.; Wu, X.; Tian, S.-K.“Stereoselective Olefination and Regiospecific Vicinal Difunctionalization of Imines with α-(Benzothiazol-2-ylsulfonyl) Carbonyl Compounds.”Eur. J. Org. Chem. 2012, 1590-1596.